|
KMID : 0939920230550041171
|
|
대한암학회지
2023 Volume.55 No. 4 p.1171 ~ p.1180
|
|
|
Sublobar Resection versus Stereotactic Body Radiation Therapy for Clinical Stage I Non?Small Cell Lung Cancer: A Study Using Data from the Korean Nationwide Lung Cancer Registry
|
|
Yun Jeong-Hee
Cho Jong-Ho
Hong Tae-Hee
Yang Kyung-Mi
Ahn Yong-Chan
Kim Hong-Kwan
|
|
|
Abstract
|
|
|
Purpose : Stereotactic body radiotherapy (SBRT) had been increasingly recognized as a favorable alternative to surgical resection in patients with high risk for surgery. This study compared survival outcomes between sublobar resection (SLR) and SBRT for clinical stage I non?small cell lung cancer (NSCLC).
Materials and Methods : Data were obtained from the Korean Association of Lung Cancer Registry, a sampled nationwide database. This study retrospectively reviewed 382 patients with clinical stage I NSCLC who underwent curative SLR or SBRT from 2014 to 2016.
Results : Of the patients, 43 and 339 underwent SBRT and SLR, respectively. Patients in the SBRT group were older and had worse pulmonary function. The 3-year overall survival (OS) rate was significantly better in the SLR group compared with the SBRT group (86.6% vs. 57%, log-rank p < 0.001). However, after adjusting for age, sex, tumor size, pulmonary function, histology, smoking history, and adjuvant therapy, treatment modality was not an independent prognostic factor for survival (hazard ratio, 0.99; 95% confidence interval, 0.43 to 2.77; p=0.974). We performed subgroup analysis in the following high-risk populations: patients who were older than 75 years; patients who were older than 70 years and had diffusing capacity of lung for carbon monoxide ≤ 80%. In each subgroup, there were no differences in OS and recurrence-free survival between patients who underwent SLR and those who received SBRT.
Conclusion : In our study, there were no significant differences in terms of survival or recurrence between SBRT and SLR in medically compromised stage I NSCLC patients. Our findings suggest that SBRT could be considered as a potential treatment option for selected patients.
|
|
|
KEYWORD
|
|
|
Radiosurgery, Sublobar resection, Non-small cell lung carcinoma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|
|